First Baby Born To Woman With Uterus From Deceased Donor

Transplant surgeon Dr Wellington Andraus left with magnifying glasses and Dr Dani Ejzenberg second left confer with colleagues at the Hospital das Clinicas of the University of Sao Paulo School of Medicine Sao Paulo Brazil

The world's first baby born by a uterus transplant from a deceased donor is healthy and nearing her first birthday, according to a new case study published Tuesday in the Lancet. She has a disease called Mayer-Rokitansky-Kuster-Hauser Syndrome, commonly known as congenital uterine absence. Seven months after the transplant, doctors transferred an embryo made via in-vitro fertilization from the woman's egg and her husband's sperm into her womb. In this case, a cesarean section was performed for birth at 35 weeks gestation, and along with the delivery of an nearly 6 pound healthy baby girl, the uterus was also removed.

While womb transplants from living donors have been successful, womb transplants from deceased donors still need to be researched, as none of the deceased donor transplants has until now resulted in conception and birth. "However, the need for a live donor is a major limitation as donors are rare, typically being willing and eligible family members or close friends". The birth resulting from the case detailed in the Lancet, which took place at Brazil's Hospital das Clínicas last December, is both the first in the world to involve a uterus from a deceased woman, and the first from any uterus transplant in Latin America.

Previously, there have been 10 other uterus transplants from dead donors attempted in the United States, Czech Republic and Turkey, but this is the first to result in a live birth. Two babies have been born at Baylor University Medical Center in Texas and one in Serbia, also from transplants from living donors.

Research leader Dr Dani Ejzenberg, of Universidade de Sao Paulo in Brazil, said: "The use of deceased donors could greatly broaden access to this treatment and our results provide proof-of-concept for a new option for women with uterine infertility".

It's still early days, but so far, there are no complaints.

He said any doubts he had about the potential importance of uterus transplants were erased after meeting the mother of the first baby born after a live donor uterus transplant.

"There are still lots of things we don't understand about pregnancies, like how embryos implant", said Dr. Cesar Diaz told USA Today.

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He traveled to Sweden to learn from doctors there who have the most experience with uterine transplantation.

The uterus transplant, in this case, happened in September 2016.

There have been several successful pregnancies using uterus transplants from live donors, since the procedure was pioneered by Swedish doctor Mats Brannstrom about five years ago. The healthy infant weighed around six pounds at birth, and continues to develop normally.

In the end, they held off an additional month after tests suggested the lining of the donor uterus wasn't quite thick enough to support implantation.

The recipient received five immunosuppression drugs (needed to prevent rejection of the new uterus by the body), antibiotics, anti-blood clotting treatment and aspirin while in hospital. The uterus was removed from recipient post that. Uterine transplants are considered "ephemeral", meaning they only stay in to allow the recipient to have children and are then removed.

Some who were born without a uterus, other had unexplained malformations, of sustained damaged during childbirth or infection.

According to reports, the success of this procedure means that there will be a larger option of donors available for those who have trouble conceiving because of uterine factor infertility.

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