[H]ardOCP: We Can Now Successfully Transplant Lab-Grown Lungs in Pigs

The organs transplanted into the pigs were built in a laboratory but were not made from scratch researchers said

A research team at the University of Texas Medical Branch at Galveston have bioengineered lungs and transplanted them into adult pigs with no medical complication. In a milestone study, researchers have successfully transplanted lungs bio-engineered into living pigs.

A bioengineered lung is produced using a support scaffold, which the researchers explain is the "skeleton" of a lung after the cells and blood have been eliminated using a detergent/sugar mixture.

The doctors are hoping that within a decade, lab-grown human lungs will be transplanted into patients to save them from chronic lung diseases, cystic fibrosis and anything that threatens life and lungs. Researchers harvested cells for the bioengineered lungs from the the pigs' lungs, using those to produce tissue for the transplant lungs that are matched to the recipient. The work, which was recently detailed in a study published by Science Translational Medicine, details the work and progress made over the last few years, reaching the point where no complication resulted from the transplants. For instance, in just two weeks, the transplanted lungs had established a stable network of blood vessels, which it needs in order to survive.

The team found that before the pigs were euthanized, the transplanted lungs developed without any outside help, building blood vessels they needed for survival.

UN condemns 'shocking' Yemen Al-Tharwa hospital strike in Hodeida
The war has left almost 10,000 people dead and unleashed what the United Nations describes as the world's worst humanitarian crisis.

Britons suffer as Spain and Portugal experience record temperatures
Ninety-one people died in a wildfire in Greece last month. "I've been here in the summer but it has never been this hot". As Europe bakes in another heatwave, forecasters say the all-time temperature record could be broken in the coming days.

Abstaining from alcohol in middle age can increase dementia risk
Downing up to six pints of beer or glasses of wine a week protects against dementia , a study suggests. A total of 397 cases of dementia were recorded over the 23 years in which the study took place.

"We were also able to improve from small animal studies to then transplanting them into a larger animal with a larger lung". The lung scaffold was placed into a tank filled with a carefully blended cocktail of nutrients and the animals' own cells were added to the scaffold following a carefully designed protocol or recipe.

During the experiment, the pigs' left lungs were transplanted alongside a bioengineered lung. Animal recipients were survived for 10 hours, two weeks, one month and two months after transplantation, allowing the research team to examine development of the lung tissue following transplantation and how the bioengineered lung would integrate with the body. While the lungs functioned during the study, they weren't connected to pulmonary arteries. It took 30 days to foster the organs before they were ready for transplants, but they didn't need infusions to keep working. This is an encouraging advance in the field of organ and tissue transplantation and transplantation.

The researchers said that with enough funding, they could grow lungs to transplant into people in compassionate use circumstances within 5 to 10 years.

"It has taken a lot of heart and 15 years of research to get this far", said Nichols and Cortiella.

Related news:

Hot News

isis-killer-beheading-video-story-top Fighters react to TJ Dillashaw stopping Cody Garbrandt for a second time
Aug 05, 2018 - 14:41
It was a decisive and impressive performance and gave him a strong argument as the best bantamweight of all time . He got up, though, and went right back at it with Dillashaw because it's the only way he knows how to fight.

isis-killer-beheading-video-story-top China Rejects US Request to Cut Iran Oil Imports
Aug 05, 2018 - 12:57
The US administration has vowed to impose sanctions on any company continuing to buy oil from Iran after the November 4 deadline. If the USA wants negotiations, it should stop pressures and sanctions, Qasemi was quoted as saying by official IRNA news agency.

isis-killer-beheading-video-story-top Rafa Benítez's angry message to Newcastle United owner
Aug 05, 2018 - 12:43
Wait, what? Why Keys has such a strong, and controversial opinion on Newcastle's situation is absolutely baffling. Newcastle are running out of time to get deals done with the season just a week away.

isis-killer-beheading-video-story-top Raheem Sterling won't be left on the shelf by manager Pep Guardiola
Aug 05, 2018 - 11:16
As FA Cup winners, Chelsea will put their wits against the Premier League champions with the first trophy of the campaign at stake.

isis-killer-beheading-video-story-top Terrell Owens enjoys his personal induction far from Canton
Aug 05, 2018 - 11:10
The six-time Pro Bowler compiled 15,934 receiving yards and 153 receiving touchdowns on 1,078 career receptions. And I know exactly what he brings to the table.

isis-killer-beheading-video-story-top USA judge: Progress to reunite migrant families ‘unacceptable’
Aug 05, 2018 - 10:59
Families with young children protest the separation of immigrant families with a sit-in at the Hart Senate Office Building in Washington last week.

isis-killer-beheading-video-story-top Venezuela's Nicolas Maduro's speech cut off, soldiers seen running
Aug 05, 2018 - 04:03
The minister said seven people were injured and are being treated for unspecified injuries at hospitals. State television showed him cutting short a speech as hundreds of soldiers broke ranks and scattered.

isis-killer-beheading-video-story-top Stranded Aussie criticised for treacherous solo mountain trek
Aug 05, 2018 - 03:29
RCCNZ rescue member Jeff Lunt told Radio New Zealand that he believed the man's army survival training saved his life. More than 30 people are thought to have died around the popular national park in the past decade.

isis-killer-beheading-video-story-top PM welcomes better visa access for Kiwis to the US - Ardern
Aug 05, 2018 - 03:29
Now that the end of her short maternity leave is looming, Ardern took to Facebook to talk about her return to parliament. Peters's comment during a heated debate in parliament.

isis-killer-beheading-video-story-top House of Fraser seeks new investment after C.banner cancels fundraising
Aug 04, 2018 - 22:50
Mike Ashley is understood to have already approached the retail giant with an investment offer that could save jobs and stores. The retailer employs 17,500 people - 6,000 direct and 11,500 concession staff.

isis-killer-beheading-video-story-top Bush's doctor's killing may have been act of revenge
Aug 04, 2018 - 22:17
Bush's doctors last month as Pappas, the son of a woman who died while the doctor was operating on her more than 20 years ago. Two days later, authorities charged Pappas, a former law enforcement officer as well as a skilled marksman, with murder.

isis-killer-beheading-video-story-top ‘Goat-a-Paloza’: 100 goats take over Boise neighborhood
Aug 04, 2018 - 22:14
About 100 escaped goats have munched on manicured lawns in Idaho's capital city before being rounded up and hauled away. The company came to the unusual scene with experience renting goats out to clear weeds and help with fire suppression.

isis-killer-beheading-video-story-top Bruce: 'Tottenham Hotspur nowhere near Jack Grealish price'
Aug 04, 2018 - 20:17
The North London club are said to value the young midfielder at roughly 20 million pounds. There's been discussions and that's been going on all summer.

isis-killer-beheading-video-story-top President Trump takes shot at LeBron in tweet
Aug 04, 2018 - 19:58
We saw this recently when he called Congresswoman Maxine Waters 'an extraordinarily low IQ person '. Lemon responded Saturday morning by calling out the president's controversial immigration policies.

isis-killer-beheading-video-story-top NASA to announce new astronaut class on Friday
Aug 04, 2018 - 18:56
The first flight of SpaceX's Crew Dragon is expected in April 2019, following an unmanned test in November, NASA said. NASA seems confident these dates will hold, and that the commercial crew program is finally on the home stretch.